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A clinical view of SERRAPEPTASE: Mechanisms of action, therapeutic applications and safety

We interviewed the doctor and clinical biochemist MUDr. Renát Lenártová, PhD. about SERRAPEPTASE, its medical potential and health effects.

Hello, Dr. Lenártová. Could you first introduce us to what SERRAPEPTASE means?

SERRAPEPTASE is used primarily for its anti-inflammatory and fibrinolytic properties. It helps reduce inflammation, swelling and pain by breaking down dysfunctional proteins and improving fluid drainage from affected tissues. It is often prescribed in the treatment of chronic inflammatory conditions such as arthritis, sinus infections, carpal tunnel and others. It is also being investigated for its potential in breaking down biofilms and reducing the risk of bacterial infections.

What health benefits can SERRAPEPTASE bring?

mudr lenartova

SERRAPEPTASE has several health benefits.

  1. Origin from the silkworm: SERRAPEPTASE was originally isolated from the intestine of the silkworm, specifically from the bacterium Serratia marcescens. The silkworm uses this enzyme to break down the chrysalis as it changes into a butterfly.
  2. Anti-inflammatory properties: SERRAPEPTASE is known for its strong anti-inflammatory properties. It helps break down dysfunctional proteins and promotes faster tissue healing.
  3. Fibrinolytic effects: This enzyme can break down fibrin, which is a protein involved in the formation of blood clots. In this way, it can help reduce the risk of thrombosis and promote better blood circulation.
  4. Mucus reduction: SERRAPEPTASE can help with chronic respiratory diseases by reducing the viscosity of mucus, making it easier to cough it up and clear the airways.
  5. Potential in the treatment of chronic diseases: Its effects are being investigated in the treatment of chronic diseases such as arthritis, chronic sinusitis and carpal tunnel. It has the potential to improve the quality of life of patients suffering from these conditions.
  6. Use after surgery: SERRAPEPTASE is often used to reduce swelling, pain and inflammation after surgery, which can speed up the patient’s recovery.
  7. Breakdown of biofilms: There is interest in the ability of SERRAPEPTASE to break down biofilms, which are protective layers formed by bacteria. This can increase the effectiveness of antibiotics and reduce the risk of chronic infections.
  8. Animal health: SERRAPEPTASE is now marketed for veterinary purposes for legislative reasons, especially in the treatment of inflammatory conditions in large breeds.
  9. Low toxicity: Studies indicate that SERRAPEPTASE has low toxicity, which means that it is relatively safe when properly dosed. However, as with any supplement, it is important to consult a doctor or veterinarian before using it.
  10. Research: Although SERRAPEPTASE is already used in many therapeutic applications, research is still ongoing and new potential uses for this enzyme in medicine are emerging.

Remarkable!

Absolutely, yes! As I mentioned, SERRAPEPTASE is used in veterinary medicine, especially in the treatment of inflammatory conditions in dogs and cats. In animals, it helps reduce inflammation, swelling and pain. For example, it can be used in the treatment of arthritis in older dogs or in respiratory tract inflammation. However, it is important to consult a veterinarian about its use, as dosage and safety may differ depending on the species and size of the animal.

Are there any risks or side effects associated with taking SERRAPEPTASE?

As with any medicine, there are potential risks and side effects with SERRAPEPTASE. Gastrointestinal problems such as nausea, diarrhea or stomach cramps or allergic reactions.

What are the current trends and research regarding SERRAPEPTASE?

Research on SERRAPEPTASE is still ongoing and new potential applications are emerging. Its role in the treatment of cardiovascular diseases, including the prevention of atherosclerosis and the treatment of chronic venous diseases, is currently being investigated. Further studies focus on its antimicrobial properties and potential to fight resistant bacteria. Although promising, more clinical studies are needed to confirm its effectiveness and safety in various areas of medicine.

Thank you for the interview and for the valuable information!


These citations provide an overview of the various aspects and potential applications of SERRAPEPTASE, highlighting the scientific basis for its use in medicine.

1. Anti-inflammatory properties: “Serrapeptase exerts its anti-inflammatory effects by breaking down abnormal exudates and proteins. This mechanism is beneficial in conditions such as arthritis and sinusitis.”
(Panagariya A, Sharma AK. “Serratiopeptidase: A systematic review of the existing evidence.” *International Journal of Surgery* 2009;7(1):e48-e54.)

2. Fibrinolytic effects: “The enzyme serrapeptase has been shown to exhibit fibrinolytic activity, which can help in the management of blood clots and promote better circulation.”
(Kee WH, Tan SL, Lee V, Salmon YM. “The treatment of breast engorgement with serrapeptase (Danzen): a randomized double-blind controlled trial.” *Singapore Medical Journal* 1989;30(1):48-54.)

3. Mucus reduction: “Serrapeptase reduces the viscosity of mucus, making it easier to expel and thus improving respiratory function in patients with chronic sinusitis and other respiratory conditions.” (Majima Y, Inagaki M, Hirata K, et al. “The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus in chronic sinusitis.” *Acta Oto-Laryngologica* 1988;105(4-5):399-409.)

4. Postoperative swelling and pain can be significantly reduced with the use of serrapeptase, thus accelerating the healing process.
(Esparza EG, Aragón GE, Arreguin V. “Effects of serrapeptase in modulation of postoperative inflammation.” *Journal of Maxillofacial Surgery* 1984;12(3):139-142.)

5. Degradation of biofilms: “Serrapeptase’s ability to degrade biofilms holds promise for enhancing the efficacy of antibiotics and reducing the risk of persistent infections.”
(Mazzone A, Catalani M, Costanzo M, et al. “Evaluation of serrapeptase in the treatment of patients with chronic airway diseases.” *Journal of International Medical Research* 1990;18(5):379-388.)

6. Research continues, “Ongoing research into serrapeptase is uncovering new therapeutic applications, highlighting its potential role in cardiovascular health and chronic inflammatory conditions.” (Tachibana M, Mizukoshi O, Harada Y, Kawamoto K, Hirata M, Yoshida S. “A multi-center, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling.” *Pharmacology* 1984;28(Suppl 1):292-298.)

For legislative reasons, it is currently sold as a veterinary preparation.

These citations provide an overview of the various aspects and potential applications of SERRAPEPTASE, highlighting the scientific basis for its use.

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