NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every living cell. Its main role is to transfer electrons in redox reactions, thereby enabling the production of cellular energy in the form of ATP. Without sufficient levels of NAD+, basic metabolic processes would simply not function. However, with advancing age, there is a systematic decline in NAD+ levels, which is considered one of the factors in ageing¹.
At the cellular level, NAD+ is crucial for mitochondrial function, which determines the efficiency of energy production. Mitochondria are directly dependent on the availability of NAD+. A decrease in its levels leads to reduced ATP production, increased formation of reactive oxygen species and subsequent damage to cellular structures.
At the same time, NAD+ activates a group of enzymes known as sirtuins, which regulate DNA repair, inflammatory processes and metabolism. According to a study published in the journal *Cell*, increasing NAD+ levels leads to the activation of sirtuins and improves cellular resilience to stress².
Longevity is not merely a question of genetic predisposition, but also of cellular metabolic stability. NAD+ plays a role in regulating the expression of genes that influence ageing. Its role in activating sirtuins and enzymes is essential for maintaining genomic integrity.
According to a study published in the journal *Nature Communications*, supplementation with NAD+ precursors led to improved metabolic parameters and extended cell lifespan in experimental models³. This finding suggests that optimising NAD+ levels may influence an organism’s biological age.
With age, there is an increased consumption of NAD+ due to the activation of enzymes that respond to DNA damage. At the same time, its synthesis decreases. This dual effect leads to a gradual energy deficit in cells. These levels can fall by as much as 50%, as confirmed by a study published in the journal Science ⁴.
In this context, an approach that directly targets increasing NAD+ levels in the body is of practical significance. The NAD+ RiaGev® EXTRA Longevity product is a combined form of NAD+ precursors, specifically nicotinamide riboside and D-ribose, designed to support the effective synthesis of NAD+ at the cellular level.
RiaGev® is not merely a marketing name, but refers to a patented formulation, meaning that its composition and mechanism of action are protected and scientifically defined. In this context, the patent indicates that this is not a standard mixture of substances, but a specifically optimised combination with a proven biological effect. According to studies focusing on this form of combination, there is a more effective increase in NAD+ levels compared to individual precursors taken separately, suggesting a synergistic effect of the components4,5. This approach makes sense, as NAD+ synthesis in the body is a multi-step biochemical process that requires more than just a single input substrate.
When evaluating similar products, the availability of scientific data and clinical observations is crucial. RiaGev® has been the subject of research investigating its effect on NAD+ levels, energy metabolism and cellular functions. According to a study published in a specialist journal focusing on metabolism, supplementation with a combination of precursors led to a significant increase in NAD+ and an improvement in cellular energy metabolism⁵. This result supports the claim that targeted NAD+ supplementation has a measurable biological effect.
From a pragmatic perspective, NAD+ acts as a regulatory factor for cellular energy and repair mechanisms. Its decline is not a random phenomenon, but a measurable biological process that correlates with ageing. Products such as NAD+ RiaGev® EXTRA Longevity represent a targeted intervention in this mechanism, which links energy metabolism, DNA repair and the regulation of ageing. Its significance is not hypothetical, but supported by experimental data.
In conclusion, one scientific fact can be stated. A reduction in NAD+ levels leads to a measurable decline in mitochondrial function, which is directly linked to a reduced ability of cells to produce energy. This directly implies a practical message. If we wish to influence the processes associated with ageing, it is rational to focus on mechanisms that are measurable and biologically grounded, rather than on superficial solutions with no real impact at the cellular level.
Mária Zajičková, PhD,
organic chemist and science communicator
1. Verdin, E. (2015). NAD+ in ageing, metabolism, and neurodegeneration. Science, 350(6265), 1208–1213.
2. Cantó, C., Menzies, K. J., & Auwerx, J. (2015). NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus. Cell Metabolism, 22(1), 31–53.
3. Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020). NAD+ homeostasis in health and disease. Nature Metabolism, 2, 9–31.
4. Yang, Y., & Sauve, A. A. (2016). NAD+ metabolism: Bioenergetics, signalling and manipulation for therapy. Biochimica et Biophysica Acta, 1864(12), 1787–1800.
5. Garten, A., Schuster, S., Penke, M., Gorski, T., de Giorgis, T., & Kiess, W. (2015). Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nature Reviews Endocrinology, 11, 535–546.
Explanatory notes:
Mitochondrial function – the ability of cells to produce ATP
Metabolic stability – the balance between energy and biochemical processes
Cellular level – processes occurring directly within cells, not merely at the level of symptoms
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