[button : interested : interested : CM171]
Sulforaphane is a bioactive substance of natural origin found in cruciferous vegetables such as broccoli and kale. Its occurrence is associated with a number of positive effects on human health, including the ability to induce apoptosis.
Apoptosis is a type of programmed cell death that plays an important role in the regulation of cell growth and the removal of damaged or redundant and harmful cells. The reasons for the induction of apoptosis by sulforaphane lie in its ability to influence various molecular mechanisms in cells.
One of the key mechanisms is the regulation of the expression of proteins that control cell cycles and cell growth. Sulforaphane can affect these proteins and cause cells to enter the apoptotic phase.
In addition, sulforaphane stimulates the production of reactive oxygen species (ROS), which can cause damage to cellular structures and activation of apoptotic signaling pathways.
The mechanisms by which sulforaphane contributes to cancer cell killing and induces apoptosis include:
1. Induction of detoxification enzymes: Sulforaphane activates phase II detoxification enzymes that help eliminate carcinogens from the body and protect cells from DNA damage.
2. Oxidative Stress: Sulforaphane increases the level of reactive oxygen species (ROS) in cancer cells, which can lead to cell damage and subsequent apoptosis.
Inhibition of histone deacetylases (HDACs): Sulforaphane inhibits HDAC enzymes that regulate gene expression. This inhibition can lead to reactivation of tumor-suppressor genes and suppression of tumor cell growth.
4. Activation of apoptotic pathways: Sulforaphane can activate various signaling pathways that lead to apoptosis of cancer cells, including the caspase pathway and mitochondria-dependent pathways.
5. Anti-inflammatory effects.
Due to its properties, sulforaphane has become the subject of research in the prevention and treatment of a variety of diseases, including some cancers and neurodegenerative diseases. However, research is still ongoing to elucidate the exact mechanisms by which sulforaphane affects cells and induces apoptosis.
——————————————————————————————————————————–
Study 1: “Sulforaphane induces apoptosis in human breast cancer cells by causing G2/M arrest and activating caspase-3″**
References Pledgie-Tracy, A., Sobolewski, M. D., & Davidson, N. E. (2007). “Sulforaphane induces apoptosis in human breast cancer cells by causing G2/M arrest and activating caspase-3.” Nutrition and Cancer, 57(2), 186-194.
Summary: This study found that sulforaphane induces apoptosis in human breast cancer cells by spby causing cell cycle arrest in the G2/M phase and activating caspase-3, a key enzyme in the apoptotic pathway.
Study 2: “Sulforaphane induces cell death and apoptosis in prostate cancer cells through activation of multiple apoptotic pathways “**
References: Singh, A. V., Xiao, D., Lew, K. L., Dhir, R., & Singh, S. V. (2004). “Sulforaphane induces cell death and apoptosis in prostate cancer cells through activation of multiple apoptotic pathways.” Carcinogenesis, 25(1), 83-90.
Summary: In this study, sulforaphane induced cell death and apoptosis in prostate cancer cells through activation ofmultiple apoptotic pathways, including activation of caspases and increased levels of reactive oxygen species (ROS).
Study 3: “Sulforaphane induces apoptosis via reactive oxygen species and mitochondrial pathways in murine hepatoma Hepa 1c1c7 cells “**
References. L., Xiao, H., & Singh, S. V. (2007). “Sulforaphane induces apoptosis via reactive oxygen species and mitochondrial pathways in murine hepatoma Hepa 1c1c7 cells.”. International Journal of Oncology, 31(6), 1421-1426.
Summary: This study demonstrates that sulforaphane induces apoptosis in murine hepatoma cellshepatocytes through the production of reactive oxygen species (ROS) and activation of mitochondrial apoptosis pathways.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192763/
https://www.carnomed.sk/produkty/sulforafan-extra.htm
https:// www.carnomed.sk/produkty/sulforafan-extra-xl-pure-gold-edition.htm