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MUDr. Lenártová: Carnosine, a unique substance with geroprotective properties

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Carnosine, a dipeptide molecule composed of the amino acids beta-alanine and histidine, is found in high concentrations in muscle tissues and the brain. This substance has a wide range of effects and properties that contribute to its uniqueness.

Geroprotective Properties of Carnosine

One of the most interesting properties of carnosine is its ability to act as a “geroprotector.” This term refers to substances that protect cells from aging and degenerative changes. Studies show that carnosine can extend cell life and promote cell health through a variety of mechanisms.

Experimental Evidence

Studies in cell cultures have shown that carnosine can extend the lifespan of fibroblasts and other cell types. Fibroblasts are cells that play a key role in the wound healing process and in the formation of connective tissue. Extending their lifespan has important implications for tissue regeneration and repair.

One of the mechanisms by which carnosine delays the cellular aging process is its ability to reduce the susceptibility of cells to oxidative stress and other degenerative changes. Oxidative stress is a condition in which free radicals damage cellular structures, leading to faster aging and various diseases.

Biochemical Mechanisms

Carnosine is able to neutralize free radicals and reactive oxygen species, thereby protecting cells from oxidative damage. In addition, carnosine binds to metal ions, preventing the formation of harmful compounds that can contribute to cell aging.

Conclusion

Carnosine is a fascinating molecule with many potential health benefits. Its ability to act as a geroprotector and extend cell life makes it an attractive supplement for those looking for ways to support their health and slow the aging process.

Renáta Lenártová PhD,MPH
Clinical Biochemist and Physician


References and Resources

– Hipkiss, A. R. (2009). Carnosine and its possible roles in nutrition and health. *Advances in Food and Nutrition Research*, 57, 87-154.
– Boldyrev, A. A., Aldini, G., & Derave, W. (2013). Physiology and pathophysiology of carnosine. *Physiological Reviews*, 93(4), 1803-1845.
– Bellia, F., Vecchio, G., & Rizzarelli, E. (2012). Carnosine derivatives: New multifunctional drug-like molecules. *Current Medicinal Chemistry*, 19(15), 2494-2514.

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